| Rank | City | 1900 Population | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Philadelphia | 1,293,697 | 2.1% |
| 2 | Pittsburgh | 321,616 | 3.0% |
| 3 | Allegheny | 129,896 | 2.1% |
| 4 | Scranton | 102,026 | 3.1% |
| 5 | Reading | 78,961 | 3.0% |
| 6 | Erie | 52,733 | 2.6% |
| 7 | Wilkes-Barre | 51,721 | 3.2% |
| 8 | Harrisburg | 50,167 | 2.4% |
| 9 | Lancaster | 41,459 | 2.6% |
| 10 | Altoona | 38,973 | – |
In 1900, the largest city in Pennsylvania was Philadelphia, with a population of 1,293,697. The second largest city is Pittsburgh, with a population of 321,616.
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