| Rank | City | 1880 Population | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Indianapolis | 75,056 | 4.5% |
| 2 | Evansville | 29,280 | 3.0% |
| 3 | Fort Wayne | 26,880 | 4.3% |
| 4 | Terre Haute | 26,042 | 4.9% |
In 1880, the largest city in Indiana was Indianapolis, with a population of 75,056. The second largest city is Evansville, with a population of 29,280.
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